Tirzepatide Research Peptide

Buying Tirzepatide

The price of Tirzepatide is $85.00 for a 10 mg vial, and you can buy it online here. It is in stock and ships the same working day when ordered before 2pm ET, Mon–Fri. No account is needed. Orders start at $180.00.

Shipping and payment

• Ships worldwide from Largo, FL, including across Africa, Asia, the Middle East and Latin America, in unbranded packaging that names no contents.
• 1 to 3 working days within the United States, 2 to 8 working days elsewhere. Free over $500; your country’s rate is shown at checkout. Rates and transit times.
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• Lost or damaged in transit inside 30 days ships again free. Terms.

What it is studied for

A single peptide acting at both the GIP and GLP-1 receptors, an approach that produced larger effects in metabolic models than GLP-1 agonism alone. The standard dual-agonist comparator in incretin research.

About Tirzepatide

Tirzepatide is a synthetic 39-amino-acid peptide built on the native GIP sequence rather than on GLP-1, which is what separates it from semaglutide and the other selective GLP-1 agonists in this catalogue. Thirty-seven of its residues are standard amino acids; positions 2 and 13 carry aminoisobutyric acid, a non-coded residue that resists the enzymatic cleavage which limits how long native incretins survive.

A C20 fatty diacid is attached partway along the chain. That modification binds the peptide to serum albumin, and it is the reason the molecule persists long enough for weekly rather than daily administration in the study protocols where it appears.

It was first characterised as LY3298176 by Coskun and colleagues at Eli Lilly in 2018. Later receptor-level work described its activity as imbalanced and biased — markedly more potent at the GIP receptor than at GLP-1, and recruiting β-arrestin differently from either native ligand. That asymmetry, rather than simple dual agonism, is the property most incretin research now examines it for.

References

1. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept Coskun T, et al. Molecular Metabolism, 2018;18:3–14
2. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist Willard FS, et al. JCI Insight, 2020
3. Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes Thomas MK, et al. J Clin Endocrinol Metab, 2021

Linked for provenance. Published research on a compound is not a statement about this product, and nothing here is a recommendation for use.

Handling

Bring the vial to room temperature before opening, add diluent slowly down the inside wall rather than onto the powder, and let it dissolve undisturbed — no shaking. Store refrigerated on arrival, and refrigerate the solution once reconstituted.

The full method, and a calculator for the draw volume at any fill weight and diluent combination.

Compared with

• Tirzepatide vs Semaglutide What is the difference between semaglutide and tirzepatide?
• Tirzepatide vs Retatrutide What is the difference between tirzepatide and retatrutide?

Questions