Methylcobalamin B12 Research Compound

Buying B12

The price of Methylcobalamin B12 is $42.00 for a 10 ml vial, and you can buy it online here. It is in stock and ships the same working day when ordered before 2pm ET, Mon–Fri. No account is needed. Orders start at $180.00.

Shipping and payment

• Ships worldwide from Largo, FL, including across Africa, Asia, the Middle East and Latin America, in unbranded packaging that names no contents.
• 1 to 3 working days within the United States, 2 to 8 working days elsewhere. Free over $500; your country’s rate is shown at checkout. Rates and transit times.
• Pay by Zelle, Cash App and Apple Pay — choose one at checkout and we email the instructions. Cryptocurrency is also accepted and takes 2% off. How payment works.
• Lost or damaged in transit inside 30 days ships again free. Terms.

What it is studied for

The methylated cobalamin form, used as a cofactor in methylation research and stocked because it appears in the same protocols as the metabolic compounds.

About B12

Methylcobalamin is not a peptide at all, and sits in this catalogue because it appears alongside the metabolic compounds rather than because it resembles them. It is a cobalamin: a corrin ring wrapped around a single cobalt atom, with a methyl group bound directly to that cobalt.

That cobalt–carbon bond is the unusual part. Organometallic bonds of this kind are rare in biology, and it is what makes the molecule a methyl donor rather than simply a source of cobalt. Only two cobalamin forms carry it — methylcobalamin and adenosylcobalamin — which is why cyanocobalamin, the cheaper form sold as a supplement, is not interchangeable with this one in methylation work.

The cobalt–carbon bond is also light-sensitive. A solution left on a bench under normal room lighting degrades measurably, which is why this ships as a solution in an amber vial and should be kept dark as well as cold.

References

1. Methylcobalamin — compound summary, structure and identifiers PubChem CID 71306319, National Library of Medicine
2. Methylcobalamin, CAS 13422-55-4 — product specification Sigma-Aldrich M9756

Linked for provenance. Published research on a compound is not a statement about this product, and nothing here is a recommendation for use.

Handling

Bring the vial to room temperature before opening, add diluent slowly down the inside wall rather than onto the powder, and let it dissolve undisturbed — no shaking. Store refrigerated on arrival, and refrigerate the solution once reconstituted.

The full method, and a calculator for the draw volume at any fill weight and diluent combination.

Questions